<B>Д 64.051.33 (Медичні науки) </B>
Постійне посилання колекціїhttps://ekhnuir.karazin.ua/handle/123456789/15269
14.01.02 — внутрішні хвороби;
14.01.03 — хірургія;
14.03.08 — імунологія та алергологія
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Документ Алергічні хвороби та хронічна Епштейна-Барр вірусна інфекція: патогенез, діагностичні підходи і терапевтична тактика ведення хворих(Харків : Хнаціональний університет імені В.Н. Каразіна, 2021) Зубченко, Світлана Олександрівна; Zubchenko, Svitlana O.Zubchenko S.O. Allergic diseases and chronic Epstein-Barr virus infection: pathogenesis, diagnostic approaches and therapeutic tactics of patient management. – Manuscript. Thesis for obtaining a scientific degree of Doctor of Medical Sciences by specialty 14.03.08 “Immunology and Allergology”, V.N. Karazin Kharkiv National University of the Ministry of Education and Science of Ukraine, Kharkiv, 2021. Regional features of sensitizing profile based on the multiplex determination of sIgE (ALEX-test) in patients with allergic diseases living in the western regions of Ukraine were identified and a comparative analysis was performed depending on the patients’ place of residence (Lviv and other oblasts of western Ukraine, urban / rural). Regional and molecular endotypes of different nosologies of allergic diseases were distinguished as well as threshold values of sensitization with regard to causative allergens. Molecular-prognostic models of personalized risk of persistent allergic diseases development (86.5%, p <0.001), intermittent allergic diseases (75.0%, p <0.01), BA (84.6%, p <0.001) have been identified for the patients with the active phase of EBV-infection.Документ Імунопатогенез інфекційного реактивного артриту на тлі активованих облігатних інфекцій (Chlamydia trachomatis та Епштейна-Барр вірус), тактика ведення хворих(Харків : Харківський національний університет імені В.Н. Каразіна, 2021) Ломіковська, Марта Павлівна; Lomikovska, M.P.Lomikovska M.P. Immunopathogenesis of infectious reactive arthritis in the background of activated obligate infections (Chlamydia trachomatis and Epstein-Barr virus), patient surveillance. - As manuscript. The thesis for the scientific degree of the candidate of medical sciences in specialty 14.03.08 – Immunology and Allergology. – Danylo Halytsky Lviv National Medical University, V. N. Karazin Kharkiv National University, Kharkiv, 2021. The thesis is dedicated to the improvement of the efficiency of treatment and forecasting of the risks of transformation of reactive arthritis (ReA) into rheumatoid arthritis (RA) through the study of the peculiarities of immunopathogenesis in the background of Chlamydia trachomatis (C. trachomatis) and Epstein-Barr virus (EBV). The rate of activity of the inflammatory process under the DAREA index was higher in patients with RеА with combined infection as compared to the group of patients with RеА with C. trachomatis (p<0,05). Molecular and genetic studies have been established: the detection of the DNA of C. trachomatis (in blood serum and in the urinogenital scraping) and Epstein-Barr virus (in blood, saliva, mucous membrane of the posterior pharyngeal wall scraping) as well as specific molecules of immunoglobulin М and immunoglobulin G (IgМ, IgG) to causative antigens.