Одержання гем-дифтор-енінових сполук та дослідження реакції їх гідросилілювання

Abstract

Organofluorine compounds hold a significant position in pesticide development and pharmaceutical research due to the unique properties of fluorine atom. However, the synthesis of organofluorine compounds is highly challenging, and effectively introducing fluorinated groups has become one of the major obstacles in the design of new drugs and agricultural chemicals. Among all fluorinated groups, difluoromethyl (CF2H) has attracted considerable attentions due to its potential to significantly influence or modulate the physical and chemical properties as well as pharmacological characteristics of molecules based on the design of their electronic distribution in biology. Therefore, exploring new reaction systems for introducing difluoromethyl groups is of great interest in synthetic chemistry. Therefore, this thesis focuses on the synthesis of embedded gem-difluoro-1,4-ene-ynes and related functional molecules through the propargylation reaction of various nucleophiles with quaternary ammonium salt substrates, without the need for metal catalysts. Additionally, subsequent functional group transformations of these molecules, including the asymmetric hydrosilylation reaction of gem-difluoro-1,3-enynes, were studied in this work.