Оптимізація інтенсивної терапії в періопераційному періоді багатоетапної оперативної корекції з періодами очікування при політравмі

Abstract

Matvieienko M.S. Optimization of intensive care in the perioperative period of multistage surgery correction with waiting periods at polytrauma. – Qualification scholarly paper: a manuscript. Thesis submitted for obtaining the Doctor of Philosophy degree in specialty 222 – Medicine (22 – Health Care). – V.N. Karazin Kharkiv National University, Ministry of Education and Science of Ukraine, 2020. The study is devoted to investigation of the effects, justification of the metabolic drugs administrution as a component of intensive care in the perioperative period of multistage surgery correction with waiting periods at polytrauma. The special significance of acute massive blood loss in the pathogenesis of traumatic disease is currently considered indisputable. That is why eliminating the deficit of circulating blood volume is a priority of intensive care. Hypoxia, hypoperfusion, ischemia quickly lead to the activation of protective and adaptive reactions and subsequently to secondary tissue damage. There is very limited information about the development, the severity of adaptive reactions in severe combined trauma on the background of operative stress when it is necessary to conduct a series of staged surgical interventions. The level of mortality and complications in multiple trauma remains very high throughout the world. In this regard, it seems important to study and implement new treatment algorithms using effective metabolic means of pharmacological correction.