Вікові особливості зміни показників клітинного та гуморального імунітету після дії інфекційних антигенів в експерименті

Abstract

Thesis for a Candidate Degree in Biology: Speciality 03.00.13 – Human and Animal Physiology (Biology). –V. N. Karazin Kharkiv National University, the Ministry of Education and Science of Ukraine, Kharkiv, 2017. For solving of fundamental problems of geriatric and gerontological health practices it is important to ascertain the presence and nature of possible age-related changes of the immune response to natural and synthetic antigens in ontogenesis on the background of the formation of secondary adaptive immunity. The body selects these or those mechanisms of defense against alien antigens based on their immunogenicity and pathogenicity. On the first stage of the protection against alien antigens the barrier function of antigenpresenting cells, the destruction of the antigen depends on their ability to phagocytosis are carried out. The following cascade of individual reactions which provide the immune protection in all stages of ontogenesis is also important. It is known that in case of insufficient function of one of the units of immunoreactivity can be activated compensatory or a function of other factors of immunity in different age groups.