Біохімічні механізми довготривалого впливу малих концентрацій кадмію на організм щурів

Abstract

WU Sі. Biochemical mechanisms of long-term effects of the cadmium low concentrations on the rats’ organism. – Qualification scientific paper, manuscript. Thesis for a Candidate Degree in Biology: Speciality 03.00.04 – Biochemistry (Biology). – V. N. Karazin Kharkiv National University of the Ministry of Education and Science of Ukraine, Kharkiv, 2019. In the thesis, in vivo and in vitro experiments conducted a study of the long-term effects of low concentrations of cadmium on 3-month-old Wistar rats at the levels of the organism, a number of its organs, the cells and molecular. Cd2+ was found to be at concentrations of 0.1 and 1 μg/kg/day, which are 5.5 and 8.3 times less than MRL and PTWI, respectively, with daily intake of rats for 5 weeks during the first 2 weeks stop the growth of animals, which resumes after 3 weeks of the experiment. Unlike the total weight of the body, the masses of all investigated organs - the heart, liver, kidneys, testes grow throughout the experiment with both doses of cadmium. Naturally, as a result, the massive coefficients of organs under the action of cadmium also increase. But cadmium still affects the growth of organs. The increase in both their mass by its action and, accordingly, the mass coefficients, is significantly slower than in the control. The revealed effect of suppressing the overall growth of animals and the growth retardation of parenchymal organs is obviously an integral consequence of cadmium in metabolic processes in different organ systems. To determine the metabolic disturbances that arise from this intervention, in the blood of rats, features of biochemical parameters characterizing the various components of the general metabolism were studied.