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Документ Pneumonia in pediatric practice : methodical recommendations(Kharkiv : V. N. Karazin Kharkiv National University, 2019) Khadzynova, I. V.; Rakovska, L. O.; Хаджинова, Юлія Володимирівна; Раковська, Людмила ОлександрівнаThe methodological recommendations present the etiology, pathogenesis, features of the clinical course and treatment of pneumonia in childhood. Methods of diagnosis, treatment and prevention of this pathology in children are given. Methodical recommendations are worked out on the basis of the Program of discipline of «Pediatrics» for students of higher medical educational institutions of III–IV levels of accreditation, authorized by Ministry of Health of Ukraine. These recommendations are intended for the 4th year English-speaking medical students.Документ Periods of the children’s life: methodical recommendations for the students of IIІ course of the medical faculty(Kharkiv : V. N. Karazin Kharkiv National University, 2018) Bugaevska, M. O.; Zimnytska, T. V.; Бугаєвська, Мар’яна Олександрівна; Зімницька, Тетяна ВасилівнаMethodical recommendations are devoted to the development of a child from the moment of conception to the age of 18. A detailed description of each period of intrauterine and extrauterine life is provided. The pathological conditions of the child in different age periods are described. Methodical recommendations are worked out on the basis of the Program of discipline of «Propedeutics of pediatrics» for students of higher medical educational institutions of III–IV levels of accreditation, authorized by Ministry of Health of Ukraine. These recommendations are intended for the 3th years English-speaking medical students.Документ Malnutrition in children : methodical recommendations(Kharkiv : V. N. Karazin Kharkiv National University, 2019) Bulich, I. M.; Rakovska, L. O.; Буліч, Ілона Миколаївна; Раковська, Людмила ОлександрівнаMethodical recommendations are devoted to a global medical problem in the world – protein-energy deficiency in children. The classification, diagnostic criteria of malnutritions are presented. Methods of treatment of severe forms of malnutrition are described. Special attention is paid to diet therapy in different phases of the disease. Methodical recommendations are worked out on the basis of the Program of discipline of «Pediatrics» for students of higher medical educational institutions of III–IV levels of accreditation, authorized by Ministry of Health of Ukraine. These recommendations are intended for the 4th year English-speaking medical students.Документ Immunological prophylaxis of the most common infectious diseases in children : methodical recommendations(Kharkiv : V.N. Karazin Kharkiv National University, 2019) Panko, N. O.; Rakovska, L. O.; Панько, Наталія Олександрівна; Раковська, Людмила ОлександрівнаMethodological recommendations provide information on the formation of children's immunity against the most common infectious diseases. Types of vaccines and indications for their use are described in details. A calendar of preventive vaccinations for children of different ages is provided. Methodical recommendations are worked out on the basis of the Program of discipline of «Pediatrics» for students of higher medical educational institutions of III–IV levels of accreditation, authorized by Ministry of Health of Ukraine. These recommendations are intended for the 6th year English-speaking medical students.Документ Knowledge and application of cardiovascular disease prevention guidelines among family physicians: a cross-sectional study(Skopje-Warsaw : Scientific Foundation SPIROSKI, Sciendo, 2021) Korzh, Oleksii; Nikolenko, Yevgenii; Titkova, Anna; Lavrova, Yelizaveta; Vovk, KiraBACKGROUND: Family physicians (FPs) play an important role in the prevention of cardiovascular disease (CVD). AIM: This study aims to assess the determinants of FPs’ knowledge and application of cardiovascular preventive management guidelines at primary health-care setting in Ukraine. MATERIALS AND METHODS: We performed a cross-sectional study conducted among the 226 FPs in Kharkiv Region, Ukraine. A self-administrated questionnaire was administered, exploring demographic, job characteristics, knowledge of CVD prevention guidelines, and application of CVD guidelines’ questions about the essential items related to diagnosis and management of CVD according to the international/local guidelines. RESULTS: The results show a very low level of knowledge of guidelines among FPs with 85.8% scoring below the acceptable knowledge level. The guidelines were applied below the acceptable level with 51.3% scoring below the cutoff point. The results indicate that both average scores were below the minimum acceptable level. Lack of knowledge of the CVD preventive care was considered the biggest barrier (62.8%). Lack of counseling skills was the second major barrier (37.9%). Subjectivity of the questions was considered to be the third barrier (32.6%). Lack of counseling skills was the second major barrier (37.9%). Subjectivity of the questions was considered to be the third barrier (32.6%). CONCLUSIONS: Recognizing the low level of knowledge and application of guidelines among primary care providers and working toward minimizing this problem can be through education, training, and monitoring of the application. This can potentially improve CVD preventive management among patients.Документ The long-term clinical outcomes in patients after myocardial infarction in primary care(Mangalore : Light House Polyclinic, 2021-06-30) Korzh, Oleksii; Nikolenko, Yevgenii; Titkova, Anna; Pavlova, Olena; Vovk, KiraThe aim of this study was to investigate the effect of continuous multifaceted patient-centered interventions at primary care level in patients with myocardial infarction (MI) after discharge on achieving clinical practice guideline goals and reducing the rate of hospital readmissions for cardiovascular diseases. Methods: This prospective randomized clinical study was conducted enrolled patients with MI from January 2, 2017 to December 31, 2019. Patients received medication reconciliation and education from a family physician before hospital discharge. The intervention group (IG) received continuous consultations from the family physician after discharge, whereas the control group (CG) did not. Primary outcomes included achieving blood pressure < 140/90 mmHg, low-density lipoprotein-cholesterol (LDL-C) < 70 mg/dL, and hemoglobin A1c (HbA1c) < 7% targets. The secondary outcome was major adverse cardiac events (MACEs), defined as re-hospitalization due to MI, unstable angina and stroke. Results: Two hundred and nineteen patients completed the study protocol (110 in the IG and 109 in the CG). The rate of achieving blood pressure goal was similar between the two groups. More patients in the IG achieved LDL-C and HbA1c goals than those in the CG at 1 year and 2 years post discharge. However, there was no significant difference in the cumulative incidence of MACEs between the two groups. Diabetes was the only independent predictor of rehospitalization due to a MACE. Conclusions: Family physicians interventions led to a higher rate of optimal controlled modifiable risk factors but did not significantly reduce the MACE rate in the patients with MI.Документ The impact of endothelial dysfunction on the course of metabolically associated liver disease in combination with subclinical hypothyroidism(Geneva-Covina : European Society of Medicine, 2024-08) Кolesnikova, Olena; Vovk, Kira; Titarenko, AndriyBackground. Intrahepatic endothelial dysfunction is involved in many diseases, including fatty liver disease, and in combination with other numerous mechanisms may play a role in atherosclerosis in hypothyroidism. It is possible that endothelial dysfunction markers may be important in assessing the risk of cardiovascular events in patients with metabolic-associated fatty liver disease (MAFLD) in combination with subclinical hypothyroidism. Aims. The aim of this study was to evaluate changes in endothelial dysfunction markers in patients with MAFLD in combination with subclinical hypothyroidism. Methods. We studied 298 patients aged 40-69 years with a history of MAFLD. Of these, 128 patients had a verified diagnosis of both MAFLD and subclinical hypothyroidism. In such cases, the morphological state of the vascular endothelium was assessed by counting circulating desquamated epithelial cells (CDEC) and vascular endothelial growth factor (VEGF-A) in the blood using phase-contrast microscopy and the value of these parameters was in comparison todepending on the level of thyroid stimulating hormone, insulin, age, and cardiovascular risk. Results. It was found that the level of CDEC and VEGF-A was increased in patients with MAFLD and subclinical hypothyroidism. On the one hand, thyroid stimulating hormone levels were found to be associated with endothelial dysfunction and hyperinsulinemia. On the other hand, endothelial dysfunction indices also have links with the degree of cardiovascular risk. Patients with moderate and high cardiovascular risk have a relationship between CDEC and levels of triglycerides, C-reactive protein, and сardiovascular diseases. The levels of VEGF-A and CDEC were significantly higher in the adult age group. VEGF-A levels > 273 pg/mL were associated with abnormalities in the studied parameters, including those reflecting of the liver. Conclusion. Patients with MAFLD in combination with hypertension have elevated levels of CDEC and VEGF-A, which affects the involvement of these factors in the mechanisms of endothelial dysfunction in this category. Markers of endothelial dysfunction can be used to assess the prediction of possible cardiometabolic risk.Документ Differential diagnosis of inherited, congenital and chronic diseases of respiratory tract in children : methodical recommendations for medical students of the 6 years of study(Kharkiv : V. N. Karazin Kharkiv National University, 2019) Kirianchuk, N. V.; Zimnytska, T. V.; Rakovska, L. O.; Кір’янчук, Наталія Валеріївна; Зімницька, Тетяна Василівна; Раковська, Людмила ОлександрівнаMethodical recommendations contain information about congenital defects of various parts of the respiratory tract, hereditary diseases (cystic fibrosis, idiopathic hemosiderosis, etc.). The principles of diagnosis and treatment of chronic diseases of the respiratory system in children are presented. Methodical recommendations are worked out on the basis of the Program of discipline «Pediatrics, children infectious diseases» for students of higher medical educational institutions of III-IV levels of accreditation, authorized by the Ministry of Health of Ukraine. These recommendations are intended for English-speaking medical students of the 6th year of study.Документ Вісник Харківського національного університету імені В.Н. Каразіна. Серія Медицина. Том XXXII, 3(50), 2024(Харків : Харківський національний університет імені В.Н. Карзіна, 2024) Белозьоров, Ігор Вікторович; Belozorov, Igor ViktorovychДокумент The role of lipid peroxidation and antioxidant systems in patients with infectious mononucleosis(Харків : Харківський національний університет імені В.Н. Каразіна, 2024-04-18) Drobi, SabrinInfectious Mononucleosis (IM), also known as glandular fever or mono, is a viral infection commonly caused by the Epstein-Barr virus (EBV). This condition primarily affects adolescents and young adults, leading to symptoms such as fever, sore throat, swollen lymph nodes, and fatigue. IM is often transmitted through saliva, earning it the nickname "the kissing disease." The onset of IM can be accompanied by significant discomfort and disruption to daily life, making timely recognition and management essential for affected individuals.