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Документ Organization and provision of emergency medical care in the practice of a family doctor. Providing emergency care by a family doctor in case of sudden death, convulsions and loss of consciousness in the prehospital stage(Харків : Харківський національний університет імені В.Н. Каразіна, 2024) Резніченко, Олександр Георгійович; Шерстюк, Людмила Леонідівна; Власенко, Ольга Олександрівна; Вовк, Кіра Віталіївна; Гріднєва, Світлана Вікторівна; Reznichenko, Oleksandr; Sherstiuk, Liudmyla; Vlasenko, Olga; Vovk, Kira; Grydnieva, SvitlanaThe educational and methodical guide contains general information and algorithms for providing emergency care in the practice of a primary care physician in the provision of medical care in case of sudden death, convulsions and loss of consciousness in the prehospital stage. The need to create such guide is due to the insufficient amount of educational and methodological materials that would fully correspond to these sections of the program in the educational discipline "General practice - family medicine". The educational and methodological guide can be recommended for students of higher medical educational institutions of the IV level of accreditation. The guide contains useful information for interns, general practitioners - family medicine doctors and doctors of any specialty.Документ Combination of hypertension and diabetes mellitus in the practice of a family doctor(RS Global Sp. z O.O., 2024-06-16) Вовк, Кіра Віталіївна; Шерстюк, Людмила Леонідівна; Власенко, Ольга Олександрівна; Шумова, Наталія Василівна; Резніченко, Олександр Георгійович; Кратенко, Ганна Степанівна; Vovk, Kira; Sherstiuk, Людмила; Vlasenko, Olga; Shumova, Nataliya; Reznichenko, Oleksandr ; Кratenko, GannaЗв'язок між артеріальною гіпертензією (АГ) і цукровим діабетом 2 типу цукровий діабет (ЦД 2) давно встановлено за результатами широкомасштабних епідеміологічні та популяційні дослідження. Кількість хворих на артеріальну гіпертензію в поєднанні з цукровим діабетом 2 типу неухильно зростає в останні роки, збільшуючи ризик розвиток як макро-, так і мікросудинних ускладнень, які прогресивно погіршує їхній прогноз. Холестерин ЛПНЩ також є a прогностичний показник ризику інсульту при ЦД 2 типу з поєднанням кількох факторів ризику (гіпертензія та дисліпідемія), а також ранні виявлення та раннє призначення гіполіпідемічної терапії для лікування або профілактика серцево-судинних захворювань є особливо важливим. У представленому клінічному випадку у хворого на фоні застосування розувастатину та фенофібрату було значним позитивна зміна тригліцеридів від 3,8 ммоль/л до 1,34 ммоль/л. Проблема ефективності лікування та покращення прогнозу хворих на цукровий діабет і гіпертонію залишається складним. Успіх в лікування залежить від дотримання наступних положень: ефективність антигіпертензивні властивості ліків (антигіпертензивні, гіпоглікемічні, гіполіпідемічні), здатність досягти цільовий рівень офісного артеріального тиску, САТ, оскільки у пацієнтів с цукровий діабет з артеріальною гіпертензією в основному недипперсний; досягнення і підтримання високої прихильності до терапії протягом багатьох років.Документ Characteristic of acute illness of higher education students(Харків : Харківський національний університет імені В.Н. Каразіна, 2020-09) Reznichenko, Oleksandr; Grydnieva, Svitlana; Martynenko, Maksym; Резніченко, Олександр Георгійович; Гріднєва, Світлана Вікторівна; Мартиненко, Максим ВікторовичThe problem of student health has become of great importance in recent decades and remains unresolved at the current time. The article presents the data of the study of acute morbidity of students of higher educational establishments, its frequency and structure, the gender peculiarities and the state of resistance of their organism are analyzed. Highlighted the priority diseases groups, their specificity and differences. According to the results of the study, the state of adaptation of the students' body in the first year of study was revealed. At the same time, there are signs of tension and breakdown of these mechanisms, decrease in body resistance may be primarily due to sudden changes in the habitual environment of students, impaired diet and quality of work-rest cycle, the presence of a large number of students who have bad habits, constant increase of educational and information load in the present conditions. Only 18.46 ± 1.16 % of medical high schools and even fewer students of technical high schools have 7.81 ± 0.63 % satisfactory indicators of resistance to the body, which indicates a possible discrepancy between the impact of the educational complex and external factors to the adaptive capacity of the student body. In the structure of acute morbidity prevail respiratory diseases in both study groups (KhNMU − 80.16 ± 2.58 %, KhNURE − 80.37 ± 2.61 %). Also, quite a large part was taken by diseases of the digestive system and urogenital system. Students of a technical university had worse indicators of body resistance compared to students of a medical university. It was also found that boys had poorer body resistance compared to girls in all groups. In future all this has negative social and economic consequences for the country as a whole.Документ Irritable bowel syndrome with constipation: issues of pathogenesis, diagnostics and treatment(Харків : Харківський національний університет імені В.Н. Каразіна, 2020-12) Grydnieva, Svitlana; Reznichenko Olexandr; Martynenko, Maksym; Гріднєва, Світлана Вікторівна; Резніченко, Олександр Георгійович; Мартиненко, Максим ВікторовичIssues related to the diagnosis and treatment of irritable bowel syndrome occupy one of the central places in gastroenterology, due to the fact that in recent years there has been a significant increase in the incidence of this syndrome, its long-term recurrent, often lifelong course, leading to a decrease in the performance of patients, despite good quality, and a significant cost to the health care system. Irritable bowel syndrome, despite its functional nature, occurs quite often - from 14-50% of the adult population according to population epidemiological studies, and the ratio of women to men is from 2: 1 to 4:1. In the structure of gastroenterological pathology, this disease accounts for 40 -70% of all cases of seeking medical help. Irritable bowel syndrome is a complex of functional disorders of the distal intestines, lasting more than 3 months and accompanied by abdominal pain that disappears after a bowel movement, flatulence, a feeling of incomplete bowel movement, changes in the frequency and consistency of stools. Factors in the pathogenesis of irritable bowel syndrome are dysfunction of mental activity with changes in autonomic and humoral functions; visceral hypersensitivity and impaired intestinal motility, past intestinal infection; endocrine disorders; food allergies, sedentary lifestyle; gen etic predisposition. Endothelial dysfunction has recently played an important role in the onset of irritable bowel syndrome. The most famous among the factors of vascular endothelium today are the powerful vasoconstrictor endothelin-1 and the vasodilator - nitric oxide. The study investigated the level of vasoconstrictor endothelin-1 and vasodilator of nitric oxide in patients with irritable bowel syndrome with constipation. It was found that such patients have severe endothelial dysfunction, which manifest s itself in an increase in the level of endothelin-1 (р˂0,01), a decrease in the level of nitric oxide (р˂0,01). The data obtained indicate the role of dysfunction of the vascular endothelium in the pathogenesis of irritable bowel syndrome with constipation. An inverse correlation was found between the content of endothelin -1 and nitric oxide (p˂0.01), which indicates an increase in the activity of vasoconstrictor mechanisms with a simultaneous decrease in vasodilation factors. The effectiveness of complex therapy in the group of patients in whom folic acid and zincteral were used as part of complex therapy in improving the clinical picture of the disease (complete relief of dyspeptic syndrome and a significant decrease in the severity of pain, constipation and asthenic syndromes), restoration of vascular endothelial function (significant decrease in the level of endothelin-1 and an increase in the level of nitric oxide) in comparison with the group of patients in the treatment of which only basic therapy was used.Документ Clinical and pharmacological characteristics of antianginal and anti-ischemic drugs(Харків : Харківський національний університет імені В.Н. Каразіна, 2023) Резніченко, Олександр; Reznichenko, Oleksandr; Шерстюк, Людмила; Sherstiuk, Liudmyla; Власенко, Ольга; Vlasenko, Olga; Гріднєва, Світлана; Grydnieva, Svitlana; Вовк, Кіра; Vovk, Kira; Бєляєва, Людмила; Belyaeva, LudmilaSince the emergence of the principles of evidence-based medicine, drug therapy has become one of the most dynamically developing branches of medicine. Currently, according to the Ministry of Health, over 12 thousand medicines are registered on the Ukrainian pharmaceutical market, which gives the doctor the opportunity to choose the most effective drug strategy in terms of an individualized approach to patients. The large number of drugs makes it difficult to make the best choice when choosing a drug to provide both clinically and cost-effective and safe treatments. Despite the existing strict recommendations for the treatment of certain diseases, it is necessary to move away from templates, and when choosing drugs, to use an individualized approach to each patient, which in turn requires deep knowledge, the use of scientifically based methods of pharmacotherapy. It is these tasks that are provided by clinical pharmacology, which in its essence is a methodology for the choice of drug therapy.