<B>Д 64.051.33 (Медичні науки) </B>
Постійне посилання колекціїhttps://ekhnuir.karazin.ua/handle/123456789/15269
14.01.02 — внутрішні хвороби;
14.01.03 — хірургія;
14.03.08 — імунологія та алергологія
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14 результатів
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Документ Симультанні лапароскопічні операції при жовчнокам’яній хворобі поєднаній з гастроезофагеальною рефлюксною хворобою та грижею стравохідного отвору діафрагми(Харків: ХНУ імені В.Н. Каразіна, 2021) Рибак, Ігор Михайлович; Rybak, I.M.Rybak I. M. Simultaneous laparoscopic operations in gallstone disease combined with gastroesophageal reflux disease and hernia of the esophageal orifice of the diaphragm. - Qualifying scientific work on the rights of the manuscript. The dissertation for a scientific degree of the candidate of medical sciences, specialty 14.01.03 – surgery. – V. N. Karazin Kharkiv National University, Ministry of Education and Science of Ukraine, Kharkiv, 2021. The dissertation presents a new approach to solving an urgent scientific problem – improving the results of treatment of patients with gallstone disease (GD) combined with gastroesophageal reflux disease (GERD) and hernia of the esophageal orifice of the diaphragm (HEOD) using an advanced algorithm gallbladder and esophagogastric junction and original minimally invasive methods of surgical correction, which reduces the frequency of postoperative complications, recurrences, and improves treatment outcomes. The aim of the study is to improve the results of diagnosis and treatment of patients with housing and communal services, combined with GERD and HEOD by optimizing the diagnosis, choice of surgical tactics and determination of indications for simultaneous laparoscopic interventions.Документ Імунопатологічні синдроми у хворих на системні аутоімунні хвороби: імунопатогенез та тактика ведення(Харків: ХНУ імені В.Н. Каразіна, 2021) Гайдучок, Ігор Григорович; Hayduchok, I.H.Hayduchok I. H. Immunopathological syndromes in patients with systemic autoimmune diseases: immunopathogenesis and patient surveillance. – As manuscript. The thesis for the scientific degree of the doctor of medical sciences in specialty 14.03.08 – Immunology and Allergology. – Danylo Halytsky Lviv National Medical University, V. N. Karazin Kharkiv National University, Kharkiv, 2021. This disertation is dedicated to the study of the immune - dependent and molecular genetic mechanisms of the development of immunopathological syndromes in patients with systemic autoimmune diseases, and to the study of their prevalence and management of such patients with assessment of pharmacotherapeutic and pharmacoeconomic feasibility of support therapy.Документ Патогенетична та прогностична роль біомаркерів системного запалення і неспецифічного захисту в розвитку та перебігу гастроезофагеальної рефлюксної хвороби у хворих молодого віку з автоімунним тиреоїдитом(Харків: Харківський національний університет імені В.Н. Каразіна, 2021) Пасієшвілі, Тамара Мерабівна; Pasiieshvili, Tamara M.The aim of the thesis is to optimize early diagnosis and improve the efficiency of predicting the clinical course of GERD in comorbidity with AIT based on the identification of pathogenetic biomarkers of systemic autoimmune inflammation, indicators and modulators of oxidative stress, components of the antioxidant defense system, vegetative and psycho-emotional state in young people. The thesis presents a theoretical substantiation and solution of an urgent problem of modern medicine - determination of the features of the combined course of gastroesophageal reflux disease and autoimmune thyroiditis in young people, based on a comprehensive assessment of disorders from the immune status, indicators of the antioxidant system, autoimmune changes and pathomorphological manifestations.Документ Роль основного фактора росту фібробластів в регуляції обміну сполучної тканини у хворих на пролапс мітрального клапану з цукровим діабетом I типу(Харків: ХНУ імені В.Н. Каразіна, 2021) Ніколенко, Олена Євгенівна; Nikolenko, Olena Ye.Olena Ye. Nikolenko. The role of the fibroblast growth factor-2 in the regulation of connective tissue metabolism in patients with mitral valve prolapse and type 1 diabetes mellitus. – Qualification scientific work on the rights of the manuscript. The dissertation on competition of a scientific degree of the candidate of medical sciences on a specialty 14.01.02 – internal diseases (Medical sciences) – V. N. Karazin Kharkiv National University, the Ministry of Education and Science of Ukraine, Kharkiv, 2021. The primary goal of the research is to increase the efficiency of the early diagnosis and the prognosis about the course of mitral valve prolapse (MVP) in combination with type I diabetes mellitus (DM I), by specifying the interdependences in the pathogenesis of connective tissue (CT) dysplasia of the MV and left ventricular (LV) myocardium, based on the study of the fibroblast growth factor-2 (FGF-2), CT metabolism and echocardiographic (EchoCG) data among young people.Документ Роль М1 і М2 фенотипів макрофагів у імунопатогенезі аденокарциноми молочної залози при наявності або відсутності метастазів у реґіонарних лімфатичних вузлах(Харків: ХНУ імені В.Н. Каразіна, 2021) Айкян, Артем Завенович; Aikian, Artem Z.Aikian A.Z. The role of M1 and M2 macrophage phenotypes in the immunopathogenesis of breast adenocarcinoma in the presence or absence of metastases in regional lymph nodes. – Qualification research work on the manuscript basis. Thesis for a Candidate Degree in Medical Sciences, Speciality 14.03.08 – immunology and allergology. – V. N. Karazin Kharkiv National University, 2021. The dissertation presents a new solution and theoretical generalization of the scientific problem, which consists in the established relationships between molecular biological types of breast adenocarcinoma, or breast cancer (BC), their individual pathomorphological features and metastasis to regional lymph nodes, and the representation therein of CD68+ tumor-associated macrophages (TAMs) and CD163+ TAMs to assess their prognostic and immunopathogenetic role.Документ Алергічні хвороби та хронічна Епштейна-Барр вірусна інфекція: патогенез, діагностичні підходи і терапевтична тактика ведення хворих(Харків : Хнаціональний університет імені В.Н. Каразіна, 2021) Зубченко, Світлана Олександрівна; Zubchenko, Svitlana O.Zubchenko S.O. Allergic diseases and chronic Epstein-Barr virus infection: pathogenesis, diagnostic approaches and therapeutic tactics of patient management. – Manuscript. Thesis for obtaining a scientific degree of Doctor of Medical Sciences by specialty 14.03.08 “Immunology and Allergology”, V.N. Karazin Kharkiv National University of the Ministry of Education and Science of Ukraine, Kharkiv, 2021. Regional features of sensitizing profile based on the multiplex determination of sIgE (ALEX-test) in patients with allergic diseases living in the western regions of Ukraine were identified and a comparative analysis was performed depending on the patients’ place of residence (Lviv and other oblasts of western Ukraine, urban / rural). Regional and molecular endotypes of different nosologies of allergic diseases were distinguished as well as threshold values of sensitization with regard to causative allergens. Molecular-prognostic models of personalized risk of persistent allergic diseases development (86.5%, p <0.001), intermittent allergic diseases (75.0%, p <0.01), BA (84.6%, p <0.001) have been identified for the patients with the active phase of EBV-infection.Документ Прогностичний вплив цукрового діабету 2-го типу на перебіг та лікування хронічної серцевої недостатності у пацієнтів після імплантації постійного електрокардіостимулятора(Харків : Харківський національний університет імені В.Н. Каразіна, 2021) Вороненко, Олена Сергіївна; Voronenko, O.S.Olena S. Voronenko. Prognostic influence of type 2 diabetes mellitus on the course and treatment of chronic heart failure in patients after implantation of a pacemaker. — Qualification scientific work on the rights of the manuscript. The dissertation on competition of a scientific degree of the candidate of medical sciences on a specialty 14.01.02 — internal diseases (Medical sciences) — V. N. Karazin Kharkiv National University, the Ministry of Education and Science of Ukraine, Kharkiv, 2021. In the dissertation the clinical and pathogenetic substantiation of prognostic influence of type 2 diabetes mellitus on the course of chronic heart failure, pathogenetic features and treatment tactics in patients with implantation of a permanent pacemaker are given.Документ Імунопатогенез інфекційного реактивного артриту на тлі активованих облігатних інфекцій (Chlamydia trachomatis та Епштейна-Барр вірус), тактика ведення хворих(Харків : Харківський національний університет імені В.Н. Каразіна, 2021) Ломіковська, Марта Павлівна; Lomikovska, M.P.Lomikovska M.P. Immunopathogenesis of infectious reactive arthritis in the background of activated obligate infections (Chlamydia trachomatis and Epstein-Barr virus), patient surveillance. - As manuscript. The thesis for the scientific degree of the candidate of medical sciences in specialty 14.03.08 – Immunology and Allergology. – Danylo Halytsky Lviv National Medical University, V. N. Karazin Kharkiv National University, Kharkiv, 2021. The thesis is dedicated to the improvement of the efficiency of treatment and forecasting of the risks of transformation of reactive arthritis (ReA) into rheumatoid arthritis (RA) through the study of the peculiarities of immunopathogenesis in the background of Chlamydia trachomatis (C. trachomatis) and Epstein-Barr virus (EBV). The rate of activity of the inflammatory process under the DAREA index was higher in patients with RеА with combined infection as compared to the group of patients with RеА with C. trachomatis (p<0,05). Molecular and genetic studies have been established: the detection of the DNA of C. trachomatis (in blood serum and in the urinogenital scraping) and Epstein-Barr virus (in blood, saliva, mucous membrane of the posterior pharyngeal wall scraping) as well as specific molecules of immunoglobulin М and immunoglobulin G (IgМ, IgG) to causative antigens.Документ Особливості імунної відповіді у пацієнтів із системними захворюваннями сполучної тканини за умов реактивованої герпетичної інфекції першого типу та тактика їх ведення(Харків : Харківський національний університет імені В.Н. Каразіна, 2021) Горбаль, Наталя Миронівна; Horbal, Natalya M.Horbal N.M. Features of the immune response in patients with systemic connective tissue diseases and reactivated herpes simplex virus type 1 infection and their management. - As manuscript. The thesis for the scientific degree of the candidate of medical sciences in specialty 14.03.08 – Immunology and Allergology. – Danylo Halytskyy Lviv National Medical University, V. N. Karazin Kharkiv National University, Kharkiv, 2021. The dissertation is devoted to the optimization of early detection and development of therapeutic approaches in patients with systemic connective tissue diseases under conditions of reactivated herpes simplex virus type 1 infection (CTD+HSV-1) taking into account the molecular genetic and immunological parameters of these patients.Документ Ефективність застосування в корекції імунних розладів алергенспецифічної імунотерапії та діалізату лейкоцитів у хворих на алергічний риніт у поєднанні з алергічним кон’юнктивітом(Харків : Харківський національний університет імені В.Н. Каразіна, 2021) Кузнецов, О.Г.; Kuznetsov, O.G.Kuznetsov O.G. - Efficacy in the correction of immune disorders ASIT and leukocyte dialysate in patients with allergic rhinitis in combination with allergic conjunctivitis. – Qualification research as manuscript. The thesis for the scientific degree of Candidate of medical science in the speciality 14.03.08 «Immunology and allergology». – Shupyk National Medical Academy of Postgraduate Education, the Ministry of Health of Ukraine. - Kyiv; V. N. Karazin Kharkiv National University, the Ministry of Education and Science of Ukraine, 2021. The dissertation is devoted to determining the effectiveness of non-specific and allergen-specific immunotherapy in the correction of immune disorders in patients with seasonal allergic rhinoconjunctivitis (SARC). Based on the obtained results, the means of immunotherapy of patients with SARC were improved and an algorithm of therapy was developed taking into account the severity of the disease and the nature of immune disorders.